Original Articles

  • Dierksen GA, Skehan ME, Khan MA, Jeng J, Nandigam RN, Becker JA, Kumar A, Neal KL, Betensky RA, Frosch MP, Rosand J, Johnson KA, Viswanathan A, Salat DH, Greenberg SM. Spatial relation between microbleeds and amyloid deposits in amyloid angiopathy. Ann Neurol 2010;68:545-8. [PubMed] [PMC free article]
  • Biffi A, Halpin A, Towfighi A, Gilson A, Busl K, Rost N, Smith EE, Greenberg MS, Rosand J, Viswanathan A. Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy. Neurology 2010;75:693-698. [PubMed] [PMC free article]
  • Linn J, Halpin A, Demaerel P, Ruhland J, Giese AD, Dichgans M, van Buchem MA, Bruckmann H, Greenberg SM. Prevalence of superficial siderosis in patients with cerebral amyloid angiopathy. Neurology 2010;74:1346-1350. [PubMed] [PMC free article]
  • Tomidokoro Y, Rostagno A, Neubert TA, Lu Y, Rebeck GW, Frangione B, Greenberg SM, Ghiso J. Iowa variant of familial Alzheimer's disease: accumulation of posttranslationally modified AßD23N in parenchymal and cerebrovascular amyloid deposits. Am J Pathol 2010;176:1841-1854. [PubMed] [PMC free article]
  • Verbeek MM, Kremer BP, Olde Rikkert M, van Domburg PH, Skehan ME, Greenberg SM. Cerebrospinal fluid amyloid ß40 is decreased in cerebral amyloid angiopathy. Ann Neurol 2009;66:245-9. [PubMed]
  • van Rooden S, van der Grond J, van den Boom R, Haan J, Linn J, Greenberg SM, van Buchem MA. Descriptive analysis of the Boston criteria applied to a Dutch-type cerebral amyloid angiopathy population. Stroke 2009;40:3022-7. [PubMed] [Stroke journal free article]
  • Garcia-Alloza M, Prada C, Lattarulo C, Fine S, Borrelli LA, Betensky R, Greenberg SM, Frosch MP, Bacskai BJ. Matrix metalloproteinase inhibition reduces oxidative stress associated with cerebral amyloid angiopathy in vivo in transgenic mice. J Neurochem 2009;109:1636-47. [PubMed] [PMC free article]
  • Kimberly WT, Gilson A, Rost NS, Rosand J, Viswanathan A, Smith EE, Greenberg SM. Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy. Neurology 2009;72:1230-1235. [PubMed] [PMC free article]
  • Viswanathan A, Raj S, Greenberg SM, Stampfer M, Campbell S, Hyman BT, Irizarry MC. Plasma Aß, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trial. Neurology 2009;72:268-272. [PubMed] [PMC free article]
  • Viswanathan A, Patel P, Rahman R, Nandigam RN, Kinnecom C, Bracoud L, Rosand J, Chabriat H, Greenberg SM, Smith EE. Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy. Stroke 2008;39:1988-1992. [PubMed] [PMC free article]
  • Greenberg SM, Grabowski TJ, Gurol ME, Skehan ME, Nandigam RNK, Becker JA, Garcia-Alloza M, Prada C, Frosch MP, Rosand J, Viswanathan A, Smith EE, Johnson KA. Detection of isolated cerebrovascular ß-amyloid with Pittsburgh compound B. Ann Neurol 2008;64:587-591. [PubMed] [PMC free article]
  • Smith EE, Vijayappa M, Lima F, Delgado P, Wendell L, Rosand J, Greenberg SM. Impaired visual evoked flow response in cerebral amyloid angiopathy. Neurology 2008;71:1424-1430. [PubMed] [PMC free article]
  • Nakagawa K, Sheikh SI, Snuderl M, Frosch MP, Greenberg, SM. A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis. J Neurol Sci 2008;272:186-190. [PubMed]
  • Holland CM, Smith EE, Csapo I, Gurol ME, Brylka DA, Killiany RJ, Blacker D, Albert MS, Guttmann CRG, Greenberg SM. Spatial distribution of white matter hyperintensities in Alzheimer’s disease, cerebral amyloid angiopathy, and healthy aging. Stroke 2008;39:1127-1133. [PubMed] [PMC free article]
  • Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain 2007;130:2310-2319. [PubMed] [Brain journal free article]
  • Johnson KA, Gregas M, Becker JA, Kinnecom C, Salat DH, Moran EK, Smith EE, Rosand J, Rentz DM, Klunk WE, Mathis CA, Price JC, DeKosky ST, Fischman AJ, Greenberg SM. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007;62:229-234. [PubMed]
  • Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM. Course of cerebral amyloid angiopathy-related inflammation. Neurology 2007;68;1411-1416. [PubMed]
  • Prada C, Garcia-Alloza M, Zhang-Nunes SX, Betensky RA, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of Aß from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 2007;27:1973-1980. [PubMed] [Journal of Neuroscience free article]
  • Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007;64:431-434. [PubMed]
  • Greenberg SM, Rosand J, Schneider AT, Pettigrew LC, Gandy SE, Rovner B, Fitzsimmons B-F, Smith EE, Gurol ME, Schwab K, Laurin J, Garceau D. A phase II study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord 2006;20:269-274. [PubMed]
  • Salat DH, Smith ES, Tuch DS, Benner T, Pappu V, Schwab KM, Gurol ME, Rosas HD, Rosand J, Greenberg SM. White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging. Stroke 2006;37:1759-1764. [PubMed] [Stroke journal free article]
  • Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 2006;24:516-524. [PubMed]
  • Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res 2006;1111:222-226. [PubMed]
  • Chen Y-W, Gurol ME, Rosand J, Viswanathan A, Rakich SM, Groover TR, Greenberg SM, Smith EE. Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy. Neurology 2006:67:83-87. [PubMed] [PMC free article]
  • Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, Bottiglieri T, Rosand J, Growdon JH, Greenberg SM. Plasma ß-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 2006;66:23-29. [PubMed]
  • Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 2006;26:365-371. [PubMed]
  • Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid ß protein in aging and neurodegenerative disease. Neurology 2005;65:1402-1408. [PubMed]
  • Rosand J, Muzikansky A, Kumar A, Wisco JJ, Smith EE, Betensky RA, Greenberg SM. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 2005;58:459-462. [PubMed]
  • Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol 2005;64:588-594. [PubMed]
  • Smith EE, Gurol ME, Eng JA, Engel CR, Nguyen TN, Rosand J, Greenberg SM. White matter lesions, cognition, and recurrent hemorrhage in lobar hemorrhage. Neurology 2004;63:1606-1612. [PubMed]
  • Greenberg SM, Eng JA, Ning MM, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage following lobar hemorrhage. Stroke 2004;35:1415-1420. [PubMed]
  • Eng JA, Frosch MP, Choi K, Rebeck GW, Greenberg SM. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol 2004;55:246-252. [PubMed]
  • Greenberg SM, Shin Y, Grabowski TJ, Cooper GE, Rebeck GW, Iglesias S, Chapon F, Tournier-Lasserve E, Baron J-C. Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation. Neurology 2003;60:1020-1022. [PubMed]
  • Shin Y, Cho HS, Fukumoto H, Shimizu T, Shirasawa T, Greenberg SM, Rebeck GW. Aß species, including IsoAsp23 Aß, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathologica 2003;105:252. [PubMed]
  • Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, Rebeck GW. Pathogenic effects of D23N “Iowa” mutant amyloid ß-protein. J Biol Chem 2001;276:32860-32866. [PubMed]
  • Grabowski TJ, Cho HS, Vonsattel JPG, Rebeck GW, Greenberg SM. A novel APP mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001;49:697-705. [PubMed]
  • Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy. Validation of the Boston criteria. Neurology 2001;56:537-539. [PubMed]
  • Cho HS, Hyman BT, Greenberg SM, Rebeck GW. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Aß aggregation. J Neuropathol Exp Neurol 2001;60:342-349. [PubMed]
  • Rosand J, Hylek EM, O'Donnell HC, Greenberg SM. Warfarin-related hemorrhage and cerebral amyloid angiopathy. A genetic and pathological study. Neurology 2000;55:947-955. [PubMed]
  • O'Donnell HC, Rosand J, Knudsen KA, Furie KL, Segal AZ, Chiu RI, Ikeda D, Greenberg SM. Apolipoprotein E genotype and risk of recurrent lobar intracerebal hemorrhage. New Engl J Med, 2000;342:240-245. [PubMed]
  • Greenberg SM, O'Donnell HC, Schaefer PW, Kraft, E. MRI detection of new hemorrhages. Potential marker of progression in cerebral amyloid angiopathy. Neurology 1999;53:1135-1138. [PubMed]
  • Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM. Progression of cerebral amyloid angiopathy: Accumulation of amyloid-ß40 in affected vessels. J Neuropathol Exp Neurol 1998;57:353-359. [PubMed]
  • Greenberg SM, Vonsattel JPG, Segal AZ, Chiu RI, Clatworthy AE, Liao A, Hyman BT, Rebeck GW. Association of apolipoprotein E e2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998;50:961-965. [PubMed]
  • Greenberg SM, Vonsattel JPG. Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke 1997;28:1418-1422. [PubMed]
  • Greenberg SM, Briggs ME, Hyman BT, Kokoris GJ, Taquis C, Kanter DS, Kase CS, Pessin MS. Apolipoprotein E e4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke 1996;27:1333-1337. [PubMed]
  • Greenberg SM, Rebeck GW, Vonsattel JPG, Gomez-Isla T, Hyman BT. Apolipoprotein E e4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-259. [PubMed]
  • Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the ß- amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett 1995;198:52-56. [PubMed]
  • Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted ß-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci USA 1994;91:7104-7108. [PubMed] [PMC free article]
  • Greenberg SM, Vonsattel JPG, Stakes JW, Gruber M, Finklestein SP. The clinical spectrum of cerebral amyloid angiopathy: Presentations without lobar hemorrhage. Neurology 1993;43:2073-2079. [PubMed]

Reviews, Chapters, Editorials

  • Smith EE, Greenberg SM. Beta-amyloid, blood vessels, and brain function. Stroke 2009;40:2601-2606. [PubMed] [PMC free article]
  • Greenberg SM. Small vessels, big problems. New Engl J Med 2006;354:1451-1453. [PubMed]
  • Zhang-Nunes SX, Maat-Schieman MLC, van Duinen SG, Roos RAC, Frosch MP, Greenberg SM. The cerebral ß-amyloid angiopathies: Hereditary and sporadic. Brain Pathol 2006;16:30-39. [PubMed]
  • Greenberg SM, Backsai BJ, Hyman BT. Alzheimer disease’s double-edged vaccine. Nature Med 2003;9:389-390. [PubMed]
  • Smith EE, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston criteria. Curr Atheroscler Rep 2003;5:260-266. [PubMed]
  • Rosand J, Greenberg SM. Beyond hypertension. Unraveling the causes of intracerebral hemorrhage. Stroke 2002;33:1195-1196. [PubMed]
  • Greenberg SM. Cerebral amyloid angiopathy and dementia. Two amyloids are worse than one. Neurology 2002;58:1587-1588. [PubMed]
  • Rosand J, Greenberg SM. Cerebral amyloid angiopathy. The Neurologist 2000;6:315-325.
  • Greenberg SM. Clinical aspects and diagnostic criteria of sporadic CAA-related hemorrhage. In: Verbeek, MM, Vinters, HV, de Waal, RMW (eds), Cerebrovascular Amyloidosis in Alzheimer's Disease and Related Disorders Wolters Kluwer Academic Publishers, Dordrecht, The Netherlands, 2000:3-19.
  • Greenberg SM. Cerebral amyloid angiopathy. Prospects for clinical diagnosis and treatment. Neurology 1998;50:961-965. [PubMed]
  • Greenberg SM, Hyman BT. Cerebral amyloid angiopathy and apolipoprotein E. Bad news for the good allele? Ann Neurol 1997;41:701-702. [PubMed]
  • Kosik KS, Ferreira A, Knowles, R Leclerc N, Greenberg SM. Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. in: Kosik KS et al, eds. Alzheimer's Disease: Lessons from Cell Biology, Springer-Verlag, Berlin, 1995.