Original Articles

  • Greenberg SM, Grabowski TJ, Gurol ME, Skehan ME, Nandigam RNK, Becker JA, Garcia-Alloza M, Prada C, Frosch MP, Rosand J, Viswanathan A, Smith EE, Johnson KA. Detection of isolated cerebrovascular ß-amyloid with Pittsburgh compound B. Ann Neurol 2009: In press.
  • Smith EE, Vijayappa M, Lima F, Delgado P, Wendell L, Rosand J, Greenberg SM. Impaired visual evoked flow response in cerebral amyloid angiopathy. Neurology 2008: In press.
  • Nakagawa K, Sheikh SI, Snuderl M, Frosch MP, Greenberg, SM. A new Thr49Pro transthyretin gene mutation associated with leptomeningeal amyloidosis. J Neurol Sci 2008; In press.
  • Smith EE, Egorova S, Blacker D, Killiany RJ, Muzikansky A, Dickerson BC, Tanzi RE, Albert MS, Greenberg SM, Guttmann CRG. Magnetic resonance imaging white matter hyperintensities and brain volume in the prediction of mild cognitive impairment and dementia. Arch Neurol 2008; 65:94-100.
  • Holland CM, Smith EE, Csapo I, Gurol ME, Brylka DA, Killiany RJ, Blacker D, Albert MS, Guttmann CRG, Greenberg SM. Spatial distribution of white matter hyperintensities in Alzheimer’s disease, cerebral amyloid angiopathy, and healthy aging. Stroke 2008:39:1127-1133.
  • Gudbjartsson DF, Arnar DO, Helgadottir A, Gretarsdottir S, Holm H, Sigurdsson A, Jonasdottir A, Baker A, Thorleifsson G, Kristjansson K, Palsson A, Blondal T, Sulem P, Backman VM, Hardarson GA, Palsdottir E, Helgason A, Sigurjonsdottir R, Sverrisson JT, Kostulas K, Ng MC, Baum L, So WY, Wong KS, Chan JC, Furie KL, Greenberg SM, Sale M, Kelly P, Macrae CA, Smith EE, Rosand J, Hillert J, Ma RC, Ellinor PT, Thorgeirsson G, Gulcher JR, Kong A, Thorsteinsdottir U, Stefansson K. Variants conferring risk of atrial fibrillation on chromosome 4q25. Nature 2007;448:353-357.
  • Levine JM, Snider R, Finkelstein D, Gurol ME, Chanderraj R, Smith EE, Greenberg SM, Rosand J. Early edema in warfarin-related intracerebral hemorrhage. Neurocrit Care 2007;7:58-63.
  • Shin HK, Jones PB, Garcia-Alloza M, Borrelli L, Greenberg SM, Bacskai BJ, Frosch MP, Hyman BT, Moskowitz MA, Ayata C. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain 2007;130:2310-2319.
  • Johnson KA, Gregas M, Becker JA, Kinnecom C, Salat DH, Moran EK, Smith EE, Rosand J, Rentz DM, Klunk WE, Mathis CA, Price JC, DeKosky ST, Fischman AJ, Greenberg SM. Imaging of amyloid burden and distribution in cerebral amyloid angiopathy. Ann Neurol 2007;62:229-234.
  • Kinnecom C, Lev MH, Wendell L, Smith EE, Rosand J, Frosch MP, Greenberg SM. Course of cerebral amyloid angiopathy-related inflammation. Neurology 2007;68;1411-1416
  • Prada C, Garcia-Alloza M, Zhang-Nunes SX, Betensky RA, Greenberg SM, Bacskai BJ, Frosch MP. Antibody-mediated clearance of Aß from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci 2007;27:1973-1980.
  • Bacskai BJ, Frosch MP, Freeman SH, Raymond SB, Augustinack JC, Johnson KA, Irizarry MC, Klunk WE, Mathis CA, Dekosky ST, Greenberg SM, Hyman BT, Growdon JH. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol 2007;64:431-434.
  • Goldstein JN, Fazen LE, Snider R, Schwab K, Greenberg SM, Smith EE, Lev M, Rosand J. Contrast extravasation on CT angiography predicts hematoma expansion in intracerebral hemorrhage. Neurology 2007;68:869-894.
  • Nandigam RNK, Chen Y-W, Gurol ME, Rosand J, Greenberg SM, Smith EE. Validation of intracranial area as a surrogate measure of intracranial volume when using clinical MRI. J Neuroimaging 2007; 17:74-77.
  • Greenberg SM, Rosand J, Schneider AT, Pettigrew LC, Gandy SE, Rovner B, Fitzsimmons B-F, Smith EE, Gurol ME, Schwab K, Laurin J, Garceau D. A phase II study of tramiprosate for cerebral amyloid angiopathy. Alzheimer Dis Assoc Disord 2006;20:269-274.
  • Salat DH, Smith ES, Tuch DS, Benner T, Pappu V, Schwab KM, Gurol ME, Rosas HD, Rosand J, Greenberg SM. White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging. Stroke 2006; 37:1759-1764.
  • Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis 2006;24:516-524.
  • Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res 2006;1111:222-226.
  • Chen Y-W, Gurol ME, Rosand J, Viswanathan A, Rakich SM, Groover TR, Greenberg SM, Smith EE. Progression of white matter lesions and hemorrhages in cerebral amyloid angiopathy. Neurology 2006:67:83-87.
  • Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, Bottiglieri T, Rosand J, Growdon JH, Greenberg SM. Plasma ß-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology 2006;66:23-29.
  • Robbins EM, Betensky RA, Domnitz SB, Purcell SM, Garcia-Alloza M, Greenberg C, Rebeck GW, Hyman BT, Greenberg SM, Frosch MP, Bacskai BJ. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci 2006;26:365-371.
  • Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid ß protein in aging and neurodegenerative disease. Neurology 2005;65:1402-1408.
  • Rosand J, Muzikansky A, Kumar A, Wisco JJ, Smith EE, Betensky RA, Greenberg SM. Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy. Ann Neurol 2005;58:459-462.
  • Domnitz SB, Robbins EM, Hoang AW, Garcia-Alloza M, Hyman BT, Rebeck GW, Greenberg SM, Bacskai BJ, Frosch MP. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol. Exp. Neurol 2005;64:588-594
  • Smith EE, Gurol ME, Eng JA, Engel CR, Nguyen TN, Rosand J, Greenberg SM. White matter lesions, cognition, and recurrent hemorrhage in lobar hemorrhage. Neurology 2004;63:1606-1612.
  • Greenberg SM, Eng JA, Ning MM, Smith EE, Rosand J. Hemorrhage burden predicts recurrent intracerebral hemorrhage following lobar hemorrhage. Stroke 2004;35:1415-1420.
  • Eng JA, Frosch MP, Choi K, Rebeck GW, Greenberg SM. Clinical manifestations of cerebral amyloid angiopathy-related inflammation. Ann Neurol 2004;55:246-252.
  • Greenberg SM, Shin Y, Grabowski TJ, Cooper GE, Rebeck GW, Iglesias S, Chapon F, Tournier-Lasserve E, Baron J-C. Hemorrhagic stroke associated with the Iowa amyloid precursor protein mutation. Neurology 2003;60:1020-1022.
  • Shin Y, Cho HS, Fukumoto H, Shimizu T, Shirasawa T, Greenberg SM, Rebeck GW. Aß species, including IsoAsp23 Aß, in Iowa-type familial cerebral amyloid angiopathy. Acta Neuropathologica 2003;105:252.
  • Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, Rebeck GW. Pathogenic effects of D23N “Iowa” mutant amyloid ß-protein. J Biol Chem 2001; 276:32860-32866.
  • Grabowski TJ, Cho HS, Vonsattel JPG, Rebeck GW, Greenberg SM. A novel APP mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy. Ann Neurol 2001; 49:697-705.
  • Knudsen KA, Rosand J, Karluk D, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy. Validation of the Boston criteria. Neurology 2001;56:537-539.
  • Cho HS, Hyman BT, Greenberg SM, Rebeck GW. Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Aß aggregation. J Neuropathol Exp Neurol 2001; 60:342-349.
  • Rosand J, Hylek EM, O'Donnell HC, Greenberg SM. Warfarin-related hemorrhage and cerebral amyloid angiopathy. A genetic and pathological study. Neurology 2000;55:947-955.
  • O'Donnell HC, Rosand J, Knudsen KA, Furie KL, Segal AZ, Chiu RI, Ikeda D, Greenberg SM. Apolipoprotein E genotype and risk of recurrent lobar intracerebal hemorrhage. New Engl J Med, 2000;342:240-245.
  • Rebeck GW, Cheung BS, Growdon WB, Deng A, Akuthota P, Locasio J, Greenberg SM, Hyman BT. Lack of independent associations of apolipoprotein e promoter and intron 1 polymorphisms with Alzheimer's disease. Neurosci Lett 1999;272:155-158.
  • Greenberg SM, O'Donnell HC, Schaefer PW, Kraft, E. MRI detection of new hemorrhages. Potential marker of progression in cerebral amyloid angiopathy. Neurology 1999;53:1135-1138.
  • Alonzo NC, Hyman BT, Rebeck GW, Greenberg SM. Progression of cerebral amyloid angiopathy: Accumulation of amyloid-ß40 in affected vessels. J Neuropathol Exp Neurol 1998; 57:353-359.
  • Greenberg SM, Vonsattel JPG, Segal AZ, Chiu RI, Clatworthy AE, Liao A, Hyman BT, Rebeck GW. Association of apolipoprotein E e2 and vasculopathy in cerebral amyloid angiopathy. Neurology 1998; 50:961-965.
  • Greenberg SM, Vonsattel JPG. Diagnosis of cerebral amyloid angiopathy. Sensitivity and specificity of cortical biopsy. Stroke 1997; 28:1418-1422.
  • Greenberg SM, Briggs ME, Hyman BT, Kokoris GJ, Taquis C, Kanter DS, Kase CS, Pessin MS. Apolipoprotein E e4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy. Stroke 1996; 27:1333-1337.
  • Greenberg SM, Rebeck GW, Vonsattel JPG, Gomez-Isla T, Hyman BT. Apolipoprotein E e4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol 1995;38:254-259.
  • Greenberg SM, Qiu WQ, Selkoe DJ, Ben-Itzhak A, Kosik KS. Amino-terminal region of the ß- amyloid precursor protein activates mitogen-activated protein kinase. Neurosci Lett 1995;198:52-56.
  • Greenberg SM, Kosik KS. Secreted ß-APP stimulates MAP kinase and phosphorylation of tau in neurons. Neurobiol Aging 1995;16:403-408.
  • Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS. Secreted ß-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci USA 1994; 91:7104-7108.
  • Greenberg SM, Vonsattel JPG, Stakes JW, Gruber M, Finklestein SP. The clinical spectrum of cerebral amyloid angiopathy: Presentations without lobar hemorrhage. Neurology 1993;43:2073-2079.

Reviews, Chapters, Editorials

  • Kosik KS, Ferreira A, Knowles, R Leclerc N, Greenberg SM. Linking amyloid precursor protein processing and tau-related pathology in Alzheimer's disease. in: Kosik KS et al, eds. Alzheimer's Disease: Lessons from Cell Biology, Springer-Verlag, Berlin, 1995.
  • Greenberg SM, Hyman BT. Cerebral amyloid angiopathy and apolipoprotein E. Bad news for the good allele? Ann Neurol, 1997;41:701-702.
  • Greenberg SM. Cerebral amyloid angiopathy. Prospects for clinical diagnosis and treatment. Neurology 1998;50:961-965.
  • Greenberg SM. Clinical aspects and diagnostic criteria of sporadic CAA-related hemorrhage. In: Verbeek, MM, Vinters, HV, de Waal, RMW (eds), Cerebrovascular Amyloidosis in Alzheimer's Disease and Related Disorders Wolters Kluwer Academic Publishers, Dordrecht, The Netherlands, 2000:3-19.
  • Rosand J, Greenberg SM. Cerebral amyloid angiopathy. The Neurologist 2000; 6:315-325.
  • Greenberg SM. Cerebral amyloid angiopathy and dementia. Two amyloids are worse than one. Neurology 2002;58:1587-1588.
  • Rosand J, Greenberg SM. Beyond hypertension. Unraveling the causes of intracerebral hemorrhage. Stroke 2002; 33:1195-1196.
  • Smith EE, Greenberg SM. Clinical diagnosis of cerebral amyloid angiopathy: Validation of the Boston criteria. Curr Atheroscler Rep 2003;5:260-266.
  • Greenberg SM, Backsai BJ, Hyman BT. Alzheimer disease’s double-edged vaccine. Nature Med 2003;9:389-390.
  • Zhang-Nunes SX, Maat-Schieman MLC, van Duinen SG, Roos RAC, Frosch MP, Greenberg SM. The cerebral ß-amyloid angiopathies: Hereditary and sporadic. Brain Pathol 2006;16:30-39.
  • Greenberg SM. Small vessels, big problems. New Engl J Med 2006;354:1451-1453.